Natura Bissé NB Ceutical Intensive Tolerance Booster Serum Review

Sometimes you try a product for review purposes and think well it's OK, but nothing special. Then you move on to something else and have a few issues with it. The OK product, no longer under strict review scrutiny gets slipped back in there to help calm the confused skin and without realising it you gradually realise this is love.

That's just how it was with Natura Bissé NB Ceutical Intensive Tolerance Booster Serum. I enjoyed using it, but in review mode I had my super critical hat on, and through the early summer, I found it to be OK, nothing that warranted a hefty £200+ price tag. Move forward to late summer and autumn where my skin has been stressed and I seriously don't want this bottle to run out. Nothing I've tried normalises my skin and leaves it feeling so soft, plump and refreshed the next morning as this. I might have to start a sneaky save up fund - Stay at home mum who's seen the family's real term income drop considerably over the last year speaks.


Here's what they Natura Bissé say about it:

An exquisite concentrate that instantly soothes damaged tissue and deeply moisturizes the skin. This exceptional serum is formulated with PRO-TOLERANCE PEPTIDE COMPLEX which provides a highly effective and controlled release of all of its ingredients, allowing it to act from within the skin’s strategic center and enhancing its natural self-defense mechanism. INTENSIVE TOLERANCE BOOSTER soothes and relieves all skin types, particularly sensitive and/or sensitized skin.


Helps prevent premature skin aging caused by chronic inflammation. Offers anti-gravity & anti-wrinkle effect to prevent sagging of facial contour & enhance skin density. Stimulates skin's self-defense system to shield from both internal & external aggressors.  Boosts skin's tolerance threshold & provides antioxidant effect. Accelerates skin's repairing & regenerating process. Unveils a supple, luminous, healthy & hydrated complexion. Hypoallergenic, paraben-free. Perfect for all skin types.


The ingredients list is impressively detailed, giving me a good insight into the why's of this product, both in terms of cost and quantity. Full marks here for helping me understand what I'm using.

20% of PRO-TOLERANCEPEPTIDE COMPLEX:

·      Acetyl Dipeptide-1 Cetyl Ester: a neuro-dipeptide developed exclusively at the NATURA BISSÉ laboratories that has a lifting effect since it protects the dermal matrix and fights against the loss of firmness by increasing the elastin level production. It also elevates the levels of Beta-endorphins (“happy molecules”) by promoting well-being and reducing unpleasant sensations.

·       Tripeptide-10 Citrulline and Tripeptide-1: modulate the activity of metalloproteinases (MMP-2 and MMP-3 that damage the skin’s structure), while preventing premature aging, restoring the levels of young collagen and repairing and strengthening the skin’s self-defense system as well as protecting it from irritation. It has an anti-wrinkle effect that keeps collagen levels well-balanced through a combination of peptides that address the problems associated with the different stages in the collagen cycle (production, organization and protection) and provide a comprehensive treatment to improve its quality.

·        Fermentus Glaciarum extract: a powerful anti-wrinkle ingredient that reshapes the facial contour while enhancing the formation of elastin and two types of collagen. There are 9 types of collagen in the skin, type I and type III are the most important. Type I makes up 80% of our collagen and promotes the protection of collagen. Type III is not produced in older skin, but is predominant in infant skin. This extract ensures youthful elasticity and fullness.

·      Pikea Robusta: a red algae extract, capable of neutralizing the release of specific inflammatory mediators such as Interleukina-1 alpha and counteracts the effects of certain free radicals associated with skin irritation and inflammation, thereby preventing skin redness as well as the typical symptoms of irritation. It moisturizes and increases the resistance in sensitive skin, thanks to its decongestive, soothing, repairing and softening properties.

·       Beta-Glucans: obtained from Brewer’s yeast, they strengthen the protection mechanism of the skin’s natural immunological system by protecting the Langerhans cells.

·       Shea Butter: a unique combination of lipids that makes it an excellent emollient that re-lipidizes and reinforces reinforces the lipid barrier.

·        Glycerin: attracts just the right amount of water to maintain the skin’s homeostasis.

·       Serine: is one of the naturally occurring amino acids in the NMF. Restores softness and smoothness.

·        Alantoin: skin protectant.

·        Hydrolyzed proteins from Soy and Wheat: essential nutrients that provide an extra boost of nourishment to the skin.

·         Panthenol (pro-vitamin B5): helps regenerate cells, while soothing and relieving the skin (chafed, irritated skin).

·      Amaranthus Causatus Seed extract: a natural source of anti-oxidants that contains squalene and Vitamin E as well as essential fatty acids and is rich in phytosterols that provide an anti-inflammatory effect, making it an extraordinarily rich oil that reinforces the skin’s lipid barrier.

·     Vitamin E (tocopherol): an exceptional anti-oxidant and moisturizer. When applied prior to sun exposure, it prevents cellular damage caused by sun radiation. It effectively moisturizes and prevents dehydration.

·   Aloe Vera extract: obtained from plants cultivated in optimal conditions in the Canary Islands (Spain) in accordance to ecological requirements and certified to be “organically” grown with the CRAE seal recognized by international organizations. The inner gel obtained from the leaf contains compounds called mucopolysaccharides and aloin among others which provide anti-stress, calming and soothing effects. It increases the resistance of sensitive skin by protecting against itchiness and irritation.

·       Vitamin F: essential fatty acids (Omega 3 and Omega 6) that are vital to the skin’s protective barrier; they allow the cells to recover their hydration level at their most superficial levels, thereby increasing the skin’s resistance to external aggressions while protecting it from dryness and the sensation of tightness. 


Application recomendations are as follows: Apply daily (morning and night) onto thoroughly cleansed skin. Gently massage on face, neck and décolleté until completely absorbed. Follow by applying your NATURA BISSÉ treatment cream.


I think initially I used this morning and night under my regular moisturiser, however in the post review period I 've used it alone at night on occasions when my skin has been troubled and only occasionally during the day.

I honestly never thought I would so heartily recommend such an expensive product, but I really will be sad when this runs out.

Check out the Natura Bissé website for stockists

PR Sample